Contents

 
Welcome
Introduction
Pink Book General Advice and Introduction
Antimicrobial Guidelines
Prescribing Guidelines and Pharmacokinetic Table
Correspondence and Enquiries
Disclaimer
Release Notes
May 2022
March 2022
December 2021
October 2021
July 2021
May 2021
April 2021
March 2021
February 2021
2020
December 2020
October 2020
September 2020
May 2020
March 2020
February 2020
2019
December 2019
September 2019
May 2019
February 2019
2018
December 2018
March 2018
2017
November 2017
August 2017
July 2017
2016
November 2016
October 2016
September 2016
24 May 2016
2015
3 December 2015
24 November 2015 (Release of 20th Edition)
Preferred Medicines List
Antimicrobial Guidelines
Pharmacology Guidelines
Medicines Information Service (MIS)
What we do
What we don't do
Resources
Contact
Prescribing Instructions for Medicines
General Advice
Inpatient Charting
All Outpatient and Discharge Prescriptions
After-Hours Discharge and Community Prescribing
CDHB Antimicrobial Guidelines
Penicillin Allergy
Intravenous Antimicrobial Therapy
General Antimicrobial Advice
Intravenous (IV) to Oral (PO) Switch
Antimicrobial Intravenous to Oral Switch Protocol
Antimicrobial Susceptibilities
Probenecid
Antimicrobial Dosing Guidelines (Adults) – Gentamicin/Tobramycin and Vancomycin
Gentamicin/Tobramycin Dosing Guidelines (Adults)
Gentamicin/Tobramycin Dosing in Patients with Spinal Injuries (Adults)
Paraplegic Patients
Tetraplegic Patients (including those with T1 involvement)
Gentamicin Dosing in Patients with Bacterial Endocarditis
Vancomycin Dosing Guidelines (Adults)
Intermittent Infusions
Continuous Infusions
Bone and Joint
Acute Osteomyelitis and Septic Arthritis
Cardiovascular System
Bacterial Endocarditis Prophylaxis
Dental Procedures, Tonsillectomy, and Adenoidectomy
Surgery and Procedures at Sites of Established Infection
Bacterial Endocarditis Treatment
Central Nervous System
Meningitis - Adults
Encephalitis - Herpes Simplex
Epidural Abscess
Ear, Nose and Throat
Acute Epiglottitis
Deep Neck Space Infections
Tonsillopharyngitis
Acute Rhinosinusitis
Chronic Rhinosinusitis
Eye
Conjunctivitis
Gastrointestinal System
H. Pylori Eradication
Parasitic Gastrointestinal Infections
Cholecystitis / Cholangitis
Diarrhoea – Clostridium difficile
Diarrhoea – Infection Associated
Acute Peritonitis
Methicillin Resistant S. aureus (MRSA)
Decolonisation protocol
Surgical prophylaxis
MRSA soft tissue infection
Bacteraemia
Obstetrics and Gynaecology
Group B Streptococcus Agalactiae (GBS) Prophylaxis
Bacterial Vaginosis
Candidal Vulvovaginitis
Pelvic Inflammatory Disease
Respiratory System
Infective Exacerbation of COPD
Empiric
Pathogens Known
Community-acquired Pneumonia
Empiric
Pathogens Known
Hospital-acquired Pneumonia
Aspiration Pneumonia
Influenza
Pertussis (Whooping Cough)
Sepsis
Non-immunosuppressed sepsis without apparent source
Immunosuppressed sepsis without apparent source
Post-TRUS sepsis
Sexually Transmitted Infections
Chlamydial Cervicitis / Urethritis / Proctitis
Herpes Simplex - Orofacial/Genital
Gonorrhoea
Non-Gonococcal Urethritis
Trichomoniasis
Syphilis
Skin and Soft Tissue
Infected Bite Wounds (Animal and Human)
Cellulitis - Simple and Erysipelas
Infected Ulcers (e.g. diabetic, vascular, pressure)
Necrotising Soft Tissue Infections
Mastitis/ Acute Breast Abscess
Pyomyositis
Varicella Zoster (Shingles)
Urinary Tract Infections
Uncomplicated Acute Lower Urinary Tract Infections (Cystitis) in Women
Acute Pyelonephritis or Complicated Urinary Tract Infection
Prostatitis
Prophylaxis for Urinary Catheter Placement in Orthopaedic (Including Spinal) Patients
Post-TRUS sepsis
Surgical
Surgical Prophylaxis
General Surgery
Vascular
Gynaecology
Neurosurgery
Orthopaedic
Otolaryngology
Urological
Cardiothoracic
Surgical Post-operative Antimicrobial Guidelines
Post-operative Fever
Presumed Septicaemia
Pneumonia
Urinary Tract Infection / Pyelonephritis
Abdominal Wound Infection
Limb Wound Infection
Prescribing Guidelines
Individualising Drug Therapy
Prescribing in Chronic Kidney Disease
General Advice
Pharmacokinetic Considerations
Pharmacodynamic Considerations
Medicines for which dose adjustment should be considered in chronic kidney disease
Prescribing in Liver Impairment
General Advice
Pharmacokinetic Considerations
Pharmacodynamic Considerations
Prescribing in the Frail and Elderly
General Advice
Pharmacokinetic Issues
Pharmacodynamic Issues
Pharmaceutic Issues
Medication Management
Prescribing in the Obese Adult
General Advice
Pharmacokinetic Considerations
Prescribing in Pregnancy
General Advice
Effect of Medicines on Pregnancy, Fetus, or Neonate
Predictable Risks Based on Drug Activity
Effects of Pregnancy on Medicine Pharmacokinetics
Prescribing in Breastfeeding
General Advice
Pharmacogenetics
Pharmacodynamic Associations
Pharmacokinetic Associations
Thiopurine Dosing Guideline in Immunosuppressive Therapy
Definitions
Thiopurine Methyltransferase (TPMT)
Other Monitoring
6-TGN and 6-MMP Monitoring
Routes of Administration
Oral (PO)
Sublingual/Buccal
Nasogastric Tube (NG) and Percutaneous Endoscopic Gastrostomy (PEG)
Rectal (PR)
Intravenous (IV)
Subcutaneous (SUBCUT)
Intramuscular (IM)
Transdermal
Polypharmacy Toxicities
Serotonin Toxicity
Anticholinergic Toxicity
QT Interval Prolongation
Drug-Food Interactions
Pharmacokinetics
Pharmacodynamics
Therapeutic Drug Monitoring (TDM)
Drug-specific Therapeutic Drug Monitoring (TDM) information
Adverse Drug Reaction (ADR) Reporting Guidelines
Nursing Staff
Medical Staff
Clinical Pharmacists
Previous ADRs
Assessing Adverse Drug Reactions
Drug-Drug Interactions
Pharmacokinetic (affecting drug concentrations)
Pharmacodynamic (affecting drug action)
Pharmaceutic (affecting the drug itself)
Drug Metabolism and Transport
Metabolism of Small Molecule Drugs
Metabolism of Large Molecule Drugs
Saturable Metabolism
Drug Transport
Prodrugs: Metabolism and Dosing
Prodrugs and Pharmacogenetics
Prodrugs and Drug-Drug Interactions
Cytochrome P450 Enzymes (CYPs)
CYP3A
CYP2D6
CYP2C8/9
CYP2C19
CYP1A2
Non-Cytochrome Redox Enzymes
Conjugation
Drug Transporters
Efflux Transporters
Ion Transporters (Solute Transporters)
Pharmacokinetic Table
Index