

Group B Streptococcus Agalactiae (GBS) Prophylaxis
- A common cause of sepsis in neonates.
- Prophylaxis should be given intravenously and intrapartum only.
- These antimicrobials are for GBS prophylaxis only. If chorioamnionitis is suspected, broader spectrum cover is necessary.
- If membranes have not ruptured and birth is by caesarean section the following prophylactic drug treatment is unnecessary.
Drug Treatment
- Duration: From labour onset until delivery.
benzylpenicillin
HMLSchedNZFPMLnoids
(Penicillin G)
|
IV 3 g (5 megaunits) initially
then IV 1.8 g (3 megaunits) every four hours
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- fe = 0.8, consider adjusting dose if CrCl is reduced.
Mild penicillin allergy
- fe = 0.9, consider adjusting dose if CrCl reduced.
Severe penicillin allergy
- fe = 0.9, adjust dose if CrCl reduced.
- Must be given diluted (1 g in at least 200 mL) and slowly (≤ 1000 mg/hour) to minimise infusion reactions.
Topic Code: 99238