Canterbury DHB

Context

Bacterial Endocarditis Treatment

Pathogens

Drug treatment

Empiric

Native valve

benzylpenicillin

HMLSchedNZFPMLnoids

(Penicillin G)

IV 2.4 g (4 megaunits) every four hours

AND

flucloxacillin

HMLSchedNZFPMLnoids

IV 2 g every four hours

AND

gentamicin

HMLSchedNZFPMLnoids

IV 3 mg/kg ideal body weight every 24 hours (once a day) initial dose - see gentamicin guidelines

Mild penicillin allergy

cefazolin

HMLSchedNZFPMLnoids

IV 2 g every eight hours

AND

gentamicin

HMLSchedNZFPMLnoids

IV 3 mg/kg ideal body weight every 24 hours (once a day) initial dose - see gentamicin guidelines

Severe penicillin allergy

vancomycin

HMLSchedNZFPMLnoids

See dosing guidelines (use high doses)

AND

gentamicin

HMLSchedNZFPMLnoids

IV 3 mg/kg ideal body weight every 24 hours (once a day) initial dose - see gentamicin guidelines

Prosthetic valves, implantable cardiac devices, or hospital-acquired endocarditis

flucloxacillin

HMLSchedNZFPMLnoids

IV 2 g every four hours

AND

vancomycin

HMLSchedNZFPMLnoids

See dosing guidelines (use high doses)

AND

gentamicin

HMLSchedNZFPMLnoids

IV 3 mg/kg ideal body weight every 24 hours (once a day) initial dose - see gentamicin guidelines

Penicillin allergy

Consult Infectious Diseases/Clinical Microbiology.

Pathogens Known

Consult Infectious Diseases/Clinical Microbiology.

Information about this Canterbury DHB document (99217):

Document Owner:

Not assigned (see Who's Who)

Last Updated:

March 2018 (Cardiovascular System)

Next Review Due:

March 2021

Keywords:

Note: Only the electronic version is controlled. Once printed, this is no longer a controlled document.

Topic Code: 99217