Canterbury DHB

Context

Conjugation

Substrates

Main drug classes predominantly metabolised by conjugation include:

Main Drugs

Glucuronidation

Sulfation

Acetylation

lorazepam

paracetamol

sulfamethoxazole

morphine*

steroids

isoniazid

oxazepam

methyldopa

 

paracetamol

 

 

irinotecan

 

 

atazanavir

 

 

ezetimibe

 

 

*to active metabolites

Inhibitors of glucuronidation (increase plasma concentrations of substrates)

There are multiple enzymes and the following inhibit some, not all.

atazanavir

gemfibrozil

valproate sodium

Inducers of glucuronidation (decrease plasma concentrations of substrates)

carbamazepine

phenytoin

rifabutin

phenobarbital

primadone

rifampicin

Information about this Canterbury DHB document (93355):

Document Owner:

Not assigned (see Who's Who)

Last Updated:

May 2019 (Drug Metabolism and Transport)

Next Review Due:

May 2023

Keywords:

Note: Only the electronic version is controlled. Once printed, this is no longer a controlled document.

Topic Code: 93355