Canterbury DHB

Context

Post-TRUS sepsis

Follow this guideline to treat sepsis after a Transrectal Ultrasound-guided Prostate (TRUS) biopsy.

Pathogen:

E. coli

Empiric

piperacillin+tazobactam

HMLNZFPMLnoids

IV 4 g/500 mg every eight hours

Mild penicillin allergy or risk factors for multidrug-resistant gram-negative bacilli (MDR-GNB):

meropenem

HMLNZFPMLnoids

IV 1 g every eight hours

Severe penicillin allergy

Consult Infectious Diseases/Clinical Microbiology.

Oral follow-on

If susceptibilities are not available

amoxicillin+clavulanic acid

HMLSchedNZFPMLnoids

PO 500 mg/125 mg three times a day

Mild penicillin allergy

cefalexin

HMLSchedNZFPML

PO 1000 mg four times a day

If proven susceptibility

ciprofloxacin

HMLSchedNZFPMLnoids

PO 500 mg twice a day

OR

trimethoprim+sulfamethoxazole

HMLSchedNZFPMLnoids

(co-trimoxazole)

PO 160 mg/800 mg twice a day

Information about this Canterbury DHB document (606698):

Document Owner:

Not assigned (see Who's Who)

Last Updated:

May 2022 (Sepsis)

Next Review Due:

May 2025

Keywords:

trus, post-trus

Note: Only the electronic version is controlled. Once printed, this is no longer a controlled document.

Topic Code: 606698